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Evaluation of QuickVue Influenza A+B Test for Rapid Screening of Pandemic Influenza A/H1N1 -2009 Viruses from Patients with Flu Like Syndrome of Phramongkutklao Hospital during 2009-2010

Evaluation of QuickVue Influenza A+B Test for Rapid Screening of Pandemic Influenza A/H1N1 -2009 Viruses from Patients with Flu Like Syndrome of Phramongkutklao Hospital during 2009-2010
 
ชื่อรางวัลที่ได้รับ รางวัลที่ 1 ในการประกวด Poster presentation ในการประชุมวิชาการพระมงกุฎเกล้า ครั้งที่ 39 ในวันที่ 23-25 พ.ย.2553
ชื่อโครงการวิจัย Evaluation of QuickVue Influenza A+B Test for Rapid Screening of Pandemic Influenza A/H1N1 -2009 Viruses from Patients with Flu Like Syndrome of Phramongkutklao Hospital during 2009-2010
หัวหน้าโครงการ พ.อ.หญิง ทิพย์วรรณ ชื่นจิตร
ปีที่ได้รับรางวัล 2553

Evaluation of QuickVue Influenza A+B Test for Rapid Screening of Pandemic Influenza A/H1N1 -2009 Viruses from Patients with Flu Like Syndrome of Phramongkutklao Hospital during 2009-2010
Chuenchitra T1, Hussem K2, Viputtikul K1 , Amlee P1, Ruangpung A1,  Boonsom W1, Saipin K1, Siriwathanakul K1, Tabprasit S1, Permpool P3, Kasinant S2, Samasiri T3, Samakoses R3, Klungthong C2, Jarman RG2, Gibbon RV2, Nitayaphan S1 and Sirisopana N1
1Armed Forces Research Institute of Medical Sciences- Royal Thai Army, Bangkok, Thailand; 2Virology Department, Armed Forces Research Institute of Medical Sciences - US Component, Bangkok, Thailand; 3Phramongkutklao Hospital, Bangkok, Thailand
 
Abstract
Background: A novel Influenza A/H1N1-2009 spread to most of the world’s population causing significant morbidity, mortality including economic problems. Accurate and rapid diagnosis of Pandemic Influenza A/H1N1 virus infection is important for the prevention and control of influenza epidemics and the timely initiation of antiviral treatment.
Objectives:To evaluate QuickVue Influenza A+B test and compare with real-time reverse transcriptase polymerase chain reaction (RT-PCR), gold standard, for its ability to detect Influenza A/H1N1 -2009 viruses.
Methods: Nasal swabs were collected from the patients with Flu like syndrome of Phramongkutklao Hospital between June 2009 to December 2010. Specimens were tested using QuickVue Influenza A+B test and RT-PCR.
Results: The study was conducted on 300 clinical nasal specimens. Of 300 specimens 61 (20.3%) were positive for pandemic Influenza A/H1N1 -2009. Sensitivity and specificity of QuickVue Influenza A+B test kit for H1N1 2009 were 29.5% and 99.5%, respectively. Positive predictive value was 94.7% and negative predictive value was 82.2%.
Conclusions: This study demonstrates that QuickVue Influenza A+B test showed low sensitivity but high specificity during a period of high Influenza A/H1N1-2009. Thus, we should consider false negative results of QuickVue Influenza A+B rapid test for diagnosis and then treatment as well. However, rapid test kits can still be useful in preliminary screening during pandemic situation.


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